The gameplay in Countdown Vampires is extremely reminiscent of the Resident Evil series; it is a third-person action game with survival horror elements. Throughout the game there are a number of puzzles the player is tasked with solving in order to progress. The player is initially given a tranquilizer gun that enables the player to incapacitate the enemy for a short time allowing the player to sprinkle them with “white water” which will restore humanity to the foe. Later in the game though the player will find a number of more lethal handgun, shotguns, etc. that will eliminate enemy characters in a much faster way than using the dart gun.
Countdown Vampires has a number of familiar enemy types, the most prevalent being the Vampire, while also including Werewolves, Giant Mantis creatures, giant purple Slime Monster blob beings, huge mutant Frog-like monster, and vampire Bats.