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7th ranked assassin from No More Heroes. Mild mannered postal delivery man by day, super villain with crotch laser by night.
Princess Devilotte de Death Satan IX, otherwise known as just Devilot (sometimes spelled Devilotte), first appeared as one of the selectable pilots in Cyberbots: Full Metal Madness.
Diavolo is the main antagonist of JoJo's Bizarre Adventure part 5.
Also known as Dr. Cid, he is one of the central antagonists in Final Fantasy XII and is Balthier's father. After going insane in his mad lust for power through the nethecite, he and his ethereal ally Venat stand in the way of Balthier and his allies.
Doctor M is the primary antagonist in Sly 3 and was once a member of Sly's father's gang. He has spent a lifetime trying to break into the Cooper Vault.
Is the main villain in the crash bandicoot games. And a mad scientist who's plan is always thwarted by Crash, who he created. He is thought to be a bit crazy.
Dolores Umbridge is a mean, ruthless woman hiding behind a gaudy pink exterior.
Doviculus is the main antagonist in Brütal Legend and is the leader of the Tainted Coil. He was originally supposed to be voiced by Ronnie James Dio but is now being voiced by Tim Curry.
One of the 3 evil doctors in the game Tengai Makyou II: Manjimaru. Specializes in magic.
One of the 3 evil doctors in the game Tengai Makyou II: Manjimaru.
One of the 3 evil doctors in the game Tengai Makyou II: Manjimaru. Specializes in bionics.
Drakken is a evil scientist who battles Kim Possible. Like all evil scientist he has a helper, his helpers name is Shego. Drakken is a would-be-world conquerer.
Dr. Erode is a huge green monster and acts as the final boss in Power Stone 2.
A boss character featured in multiple Clay Fighter games. He has a custom made prosthetic limb that he appears to use for insane scientific pursuits.
Dr. Malcolm Betruger was the head scientist of the Union Aerospace Corporation (UAC) on Mars. He's voiced by Philip L. Clarke.
Dr. Robotnik, also known as Dr. Eggman, is the antagonist in nearly every Sonic the Hedgehog title.
Dr. Wily is the insidious inventor of the various Robot Masters that plague the year 20XX. His jealousy and hatred for both Mega Man and Dr. Light has compelled him to mastermind various plots to do away with them throughout several games.
The player's canine hunting companion (and erstwhile source of mockery) in Duck Hunt.
male Antagonist from Tengai Makyou II: Manjimaru and a member of the evil Root Clan.
Master of Telekinesis; allowing him to move anything.
Darth Sidious is a character in George Lucas's Star Wars saga. Toward the end of his lifespan he reigned as the Emperor of the Galactic Empire. As a running politician he went by name of Sheev Palpatine, he is survived by a granddaughter called Rey.
A witch and major antagonist in the Umineko no Naku Koro ni universe, Eva-Beatrice is the successor to Beatrice as the Endless and Golden witch.
Experiment 627 is one of Dr. Jumba Jookiba's genetic experiments in Disney's "Lilo & Stitch" franchise. Stitch's evil immediate successor, he is designed to be a much improved version of Stitch with better and more powers without any of Stitch's weaknesses. He also has an extra sense of humor (his only weakness) and is designed to never be able to turn good. Lilo & Stitch fans call him "Evile" as a nickname, since all he could say in The Series was "Evil!"
(referred to as Nack the Weasel in America) A character in the Sonic the Hedgehog Games. First appeared in Sonic Triple Trouble.
Father Grigori is a character that appears in Half-life 2. The character appears in the Ravenholm chapter of the game.
A member of Dead Cell and master bomb maker. Set with his own ideals and plans for the Big Shell, Fatman is in a league of his own.
Cackletta's assistant packed with nasty gadgets and a foul tongue. Annoys Mario and Luigi to no end in their quest to save the Bean Kingdom. Known for his parodic, intentionally "poorly translated" dialogue.
Your "best friend".
The Spongebob Squarepants version of the Flying Dutchman is a pirate ghost who occasionally haunts Bikini Bottom. He has a giant ghost ship, but no ghost crew. He also has a pickle jar full of souls.
He is the king of the demon world and father of Nerine in the game/anime Shuffle!
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