Picross e2, released just 6 months after Picross e, is Jupiter's second installment of Picross for 3DS. Another 150 puzzles are included, with a different (green and white) UI design. In addition to more standard Picross puzzles, a new "Micross" mode has been added.
In Micross mode, players complete a number of 10x10 Picross puzzles that fit together to form a massive 80x80 image based on famous artwork. Five paintings are included, based on art by Leonardo da Vinci, Vincent van Gogh, Jean-François Millet, Rembrandt, and Diego Velázquez. Micross mode is similar to the large puzzles from Picross 2.