Picross 2 takes the gameplay of the original Mario's Picross and makes a few necessary tweaks here and there. For example, the numbers for the currently selected row and column are enlarged, and the numbers can be marked as a reminder that a row or column is completed.
Rather than just a grid of available puzzles, the main mode now has players controlling Mario, walking to each puzzle in an environment. The Wario's Picross mode from Mario's Super Picross also makes a return, featuring no time limits but also notification when players make a mistake. The puzzle sizes have also been bumped up - Easy Picross jumps all the way up to the 15x15 cap of the original game, while the main mode has 30x30 puzzles - each completed in four 15x15 stages.