mithical

This is tricky because music is tied particularly strong to memory for me, so to some degree a song from any game I love provokes a response. Here are a couple that seem to be stronger than most though:

Persona 3 - Kimi no Kioku

Chrono Cross - Dreamwatch of Time, Star-Stealing Girl, Life Faraway Promise

Chrono Trigger - Crono's Theme, Corridors of Time, World Revolution, To Far Away Times

Super Mario Land - Birabuto Land, Rocket Ship Ride

The Legend of Zelda: Ocarina of Time - Kokiri Forest, Hyrule Field Main Theme, Zelda's Theme, Last Battle

The Legend of Zelda: The Wind Waker - Ganondorf Battle

Phantasy Star 4 - Motavia Town, Rika, Her Last Breath, Laughter, The Edge of Fables, Ooze

I'm sure these won't effect you the same way they do me, though. Sure, maybe there's something about the music that is powerful, but I feel like you're not going to get nearly the same feeling without the memories and experiences that came along with playing the game.

EDIT: For me, these all take me back to a place and time, usually with a slightly heavy feeling in my chest. Even the happy ones are tinged with a bittersweetness of knowing I'm not actually 12 again, losing myself in a game.

After playing through the Zero Escape games I wanted to check this out and was disappointed it was Vita only, so I'm psyched this is finally happening. Now if only there was some way to get P4G...

More great examples of RNG manipulation in Tool-Assisted Speedrunning are the Shining Force runs by DarkKobold. This run of SF2 has since been improved by the same author but the RNG manipulation is only discussed in the comments there, with details about 7 Lua scripts the author created to manage the RNG.

The Blitz skill that lets you VATS teleport is pretty huge. High agility helps too because if you're good at sneaking, it's much easier to get some sneak attacks with it.

Most of the things I've picked up come from Jeff:

'Janky'

'Huh'

'In a lot of ways'

'Get up on him' (and)

'Give him the business'

'I mean... what?' (after saying something self-incriminating)

And I like to say pairs of one syllable words the way Jeff says 'Big Bo', but never when anyone can hear me. Also, I've recently noticed that Austin's 'hot minute' has started to spread around the GB East office.

If I had to estimate the number of hours I played Diablo 2 over the years (on and off until the release of D3), it'd probably get up over 1000. I had 2000 hours across all my WoW characters when I stopped playing that, too. The real kicker is I've probably put 100 hours or so in to an NES platformer called Kabuki Quantum Fighter because I speedrun it. It takes a little over 10 minutes to beat, haha.

If what you like about Metal Gear is the cool-guy-action-stuff, check out Durarara!!!

The sewer level in Shadows of the Empire terrified me and my sister back in the day. Limited visibility in the water combined with the terrifying sound those tentacle monsters make... yeesh.

The ending of Angel Beats was surprisingly moving, especially for something so action and comedy driven.

Grave of the Fireflies, for obvious reasons.

I want to mention one I haven't seen posted yet though, Anohana: The Flower We Saw That Day. If you love bittersweet tear-jerkers you need to see this.

Spooky! Which is a compliment.