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Rohan Kishibe is a manga artist who becomes a supporting character in JoJo's Bizarre Adventure part 4.
Rugal Bernstein is the final boss of The King of Fighters 94, 95, 98, 2002, Ultimate Match and Unlimited Match making him the most recurring boss and a staple of the series. He is a typical example of "SNK Boss Syndrome".
The main antagonist in The Evil Within.
Saryrn is a goddess in the EverQuest franchise. She is known as the Mistress of Pain and is the goddess of torment.
A character from the Umineko no Naku Koro ni series. She's the third eldest Sister of Purgatory and the Stake of Wrath.
Satan is the Devil, the incarnation of Evil in the universe, the Lord of Hell, the Prince of Darkness, and a very prominent figure in the Abrahamic religions. Naturally, he appears in many videogames, often as a final boss or last encounter. He is commonly depicted as a tempter that leads the faithful astray, and it's generally a bad idea to trust him.
The main villain of Disney's The Lion King.
Scarecrow is an antagonist in the Batman universe who specializes in inducing fear in his victims.
New character in the Arcana Heart series as of Arcana Heart 3.
Sebulba was the reigning champion of the Outer Rim Podrace circuit in the waning days of the Republic. Sebulba flies dirty, and will even stoop to sabotaging a competitor's Podracer before the race begins.
Secco is major antagonist in JJBA part 5.
The Shadow Queen is the main villain of Paper Mario: The Thousand-Year Door. She is also the game's final boss.
A character from the game / anime / manga Higurashi no Naku Koro ni. In reality she is Mion Sonozaki, the older twin sister, but swapped positions with the real Shion at a young age and is now Shion to everyone. Frequently carries a taser with her.
This demon was originally created by Robert E. Howard of Conan fame, but is more well known as a Marvel Comic and Capcom fighting game character. Chaos Dimension!
Sigma is the main antagonist in the Mega Man X series. He is almost always found to be the final boss in the games.
Chaos Sorcerer Sindri Myr is a Chaos Space Marine of Alpha Legion in Warhammer 40,000: Dawn of War.
A sadistic Ogre "cook" who remains quite good at what he does even having his hands chopped off and replaced with blades.
Slaanesh, the Dark Prince of chaos, is a god in the Warhammer & Warhammer 40.000 universe. Lust, pride and self-indulgence are the hallmarks of those that follow him. Slaanesh is androgynous but referred to as a "he".
An Orc Lieutenant created for Guardians of Middle-Earth
The third 'Son of Big Boss', created as part of the Les Enfants Terribles project along with Liquid and Solid Snake.
A dangerous cyborg mercenary and member of the "Winds of Destruction". Despite not officially running Desperado Enforcement LLC, he's generally believed to be pulling the strings of the PMC.
Susano'o is the true vessel of main antagonist, Terumi. who appears in Central Fiction
Takaya is the the leader of Strega, the antagonists of the player in Persona 3.
She's one of the playable characters in EN-Eins Perfektewelt.
A nightmarish fusion of Batman and the Joker, the Batman who Laughs is the leader of the Dark Knights and in many ways the most dangerous of them all. Certainly, he is the most evil.
The leader of the three Dark Captains of Sauron, he conspires to restore his master's physical form. Of the three Dark Captains, he represents Sauron's deceitfulness.
A powerful, shapeshifting servant of Tzeentch, he is a consummate trickster who enjoys playing "pranks" on others...that often leads to numerous deaths.
A "perfect" clone of Galen Marek made by Darth Vader to succeed him. Unlike the clone the player controls, the Dark Apprentice has none of the original Galen's humanity or scruples.
The playable Sith Warrior in Star Wars: The Old Republic
A sadistic, free-lance torturer looking for new ways to spread pain and misery
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