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Daniel Clarke was born in Oxford, England. Dr. Clarke was a vocal communist during his years, but when the anti-communism sentiment arose in England during the McCarthyism era, he found himself exiled by his peers. Looking for new supporters and patrons he traveled to the Soviet Union in 1964, and subsequently worked under Dragovich's Nova project, where his expertise in biology and chemistry came to play, primarily to stabilize certain volatile components in the Nova-6 gas. Clarke never directly worked with Dragovich however, but knew once his work on the project was completed, Dragovich would terminate him to prevent any loose ends.
Clarke, however, escaped. Although he intended to seek refuge at his brother's home in Johannesburg, until his capture by Hudson and Weaver at Kowloon City, Clarke was on the run the whole time, primarily from Dragovich's men. But even when he was on the run, his research continued, as samples of Nova-6 stored in canisters were present in his make-shift lab in Hong Kong.
Although he revealed that Friedrich Steiner created Nova-6, as well as the base of operation in the Soviet Union, Clarke promised to reveal information on Nova-6 if Hudson and Weaver saved him from the Russians sent by Dragovich.
They fight their way out onto the rooftops through a storm, and they are about to escape when Clarke is shot in the head by a Spetsnaz sniper before he could finish telling Hudson and Weaver details pertaining to the "numbers". Hudson then dropped his body into the alley below and escaped with Weaver down the sides of the buildings into the alley. Hudson and Weaver shoot their way out and escape without all of the important information Clarke could have provided for them.