Female characters that are comedic reliefs

Are there any female characters that are witty, funny, sarcastic and satirical?

Amy, if you mean unintentionally.

Bastila Shan in KOTOR. Just get her talking... ^^

I seem to remember that giant lesbian in Fable 2 having some funny lines.

The fat chick is always comedic relief in anything.

" The fat chick is always comedic relief in anything. "

" Morrigan from DA:O? Especially paired with Alistar...or Dog, or anyone. "

" Are there any female characters that are witty, funny, sarcastic and satirical? "

Inga Wagner in No One Lives Forever. 
 
Harley Quinn in Batman (sort of).

" The fat chick is always comedic relief in anything. "

The only two that I can think of, that weren't mentioned, are:
 
The female-voiced AI of the Normandy in Mass Effect 2 had some good moments with Joker.
Patricia Tannis from Borderlands
 
But there are definitely more male comedic characters than female.

I forget her name but the lady in Fallout 3 who send you out to make that survival guide.

" The fat chick is always comedic relief in anything. "

" The only two that I can think of, that weren't mentioned, are: The female-voiced AI of the Normandy in Mass Effect 2 had some good moments with Joker. Patricia Tannis from Borderlands  But there are definitely more male comedic characters than female. "

Para-Medic I guess, because of the codec conversations with her, especially the one about the Russian glowcaps.