Me personally

-Bioshock 2
(Loved the first one)
-COD6
(c'mon its COD, lol but no really COD4 was just plain fun)
-BFBC2
(Love the destructibility and beefy weapons)
-Singularity
(The time concept looks really interesting and the gameplay just looked fun)
-Wolfenstein
(Crazy weapons)
-Lost Planet 2
(Love the fast paced team play)
-Metal Gear Rising
(Big fan of the Metal Gear series)
-Diablo 3
(Looked fun to play with friends)
-RAGE
(Haven't seen gameplay but looks like it could promising)
-Operation Flashpoint 2: Dragon Rising
(The concept peeked my interest and I can get into hyper-realism games once in a while^^)
-Alan Wake
(Game looked fun with the use of light and great graphics^^)

(thats all I can think of at the moment will keep adding)

Star Wars: The Old Republic ( do i really need to explain?)

All that + starcarft 2.

Guild Wars 2, although I believe it won't come out until 2010/2011

I wanna see how these turn out, it doesn't necessarily mean I'm already hyped. Diablo 3, Thief 4, Deus Ex 3, Call of Juarez 2, several space MMORPGs in development, Armed Assault 2, Operation Flashpoint 2, Battlefield 3, Street Fighter IV, Assassin's Creed 2, Divine Divinity 2, the RPG from Piranha Bytes, Age of Decadence, Mount&Blade: Warband, a ton of indie games, freebies, and mods that I can't remember (like Neotokyo, omg, it's resurfaced ready for release!!!111), and other titles I likely forget as I didn't put much thought in this post.

Lots of games to look forward to but the ones that stand out for me this year are Assassin's Creed 2 and Modern Warfare 2. For next year, Diablo 3, Thief 4 and Deus Ex 3.

" I wanna see how these turn out, it doesn't necessarily mean I'm already hyped. Diablo 3, Thief 4, Deus Ex 3, Call of Juarez 2, several space MMORPGs in development, Armed Assault 2, Operation Flashpoint 2, Battlefield 3, Street Fighter IV, Assassin's Creed 2, Divine Divinity 2, the RPG from Piranha Bytes, Age of Decadence, Mount&Blade: Warband, a ton of indie games, freebies, and mods that I can't remember (like Neotokyo, omg, it's resurfaced ready for release!!!111), and other titles I likely forget as I didn't put much thought in this post. "

Jman, you named most of mine although i'll just put in my list:

Diablo 3!

StarCraft 2

Elemental: War of Magic (2010) looks interesting.

(from Stardock, the Sins of a Solar Empire and Demigod guys)

Anything made by BioWare (ME 2, DAO, SWTOR)
Anything non-WoW made by Blizzard (D3, SC2)
Lego Universe.

That's about it. 

STALKER Call of Pripyat...

Cause the first one was pretty cool, a bit frustrating at times but still.
Playing Clear Sky currently.

ArmA II, because

Apart from the obvious (Diablo 3, Starcraft 2) I'm also really looking forward to Anno 1404, which is out next week. The game looks absolutely fantastic and the demo played like a real Anno game should. Also waiting to give Supreme Commander a spin :) Cities XL and Elemental: War of Magic are somewhat lower on the list.

- Alpha Protocol (I like spy games and RPG's)
- The Agency (This game looks like it just MIGHT be different than your traditional grindfest MMO)
- Diablo 3 (Never played much of the previous ones, but this one looks pretty sweet)
- Jumpgate Evolution (Freelancer MMO!)
- Guild Wars 2 (Loved the original, still play it sometimes)
- Dragon Age: Origins (Looks like a really deep RPG experience)
- Assassin's Creed 2 (Liked the first one, and everything that I didn't like seems to be addressed here)
- Duke Nukem Forever (I can dream, right?)

" Anything made by BioWare (ME 2, DAO, SWTOR)Anything non-WoW made by Blizzard (D3, SC2)Lego Universe.That's about it.  "

Adding Dawn of Discovery to my list, I just noticed this game, looks great.

Removing it now because of the tree install limit.

-The Giantbomb iphone application........
-Dragon Age - Something to stop me playing Icewind dale 2 and Baldur's gate would be nice.

Like others have said, there is a lot to look forward to, however, my #1 has to be mass effect 2. It is supposed to hit early next year, and I am dying to play it.

" -The Giantbomb iphone application........-Dragon Age - Something to stop me playing Icewind dale 2 and Baldur's gate would be nice. "

-Call of Juarez: Bound in Blood (never played a good wild wild west game)