Today, I finished up my Borderlands playthrough and decided to keep chugging away at Assassin's Creed 2.  That's a great game which I definitely need to spend more time playing.  The only problem is that, today, I did a horrible horrible thing.  I reached Venice and had Leonardo get set up in his new workshop.  However, at the end of the little walk-about that they go through Venice, I wasn't paying attention and they prompted me to press a button to hug the dude.  I turned away for only about a second, and turned back to see the button prompt still there.  
I hit it, I guess just a half/second too late, and was greeted with Leo dropping his arms to his side and just the saddest face ever as he sullenly turned around and went inside.  I asked my brother, who had played that section a few days ago what happened, and he reinforced my greatest fears.  I had missed hugging Leonardo. 
I guess this is how you can tell that you're really connecting with a video game's world and characters, when you genuinely feel bad about missing a somewhat meaningless (from a gameplay standpoint) quick time event.  Sorry, Leo.  You know I love you, bro.     
 
UPDATE 11/15/2010: 
This very blog was referenced in a LiveScience.com article concerning Assassin's Creed and its recreation of Renaissance Italy.  I personally think that's pretty cool, so I figgered I'd update this thing with that link.  After all, this was (miraculously) my most popular blog here. 
That link for you, duders/dudettes! 
 
Thanks to all that posted and read. 
-i-Rix