Doesn't really matter, it's up to you. They don't spoil the main plot. You can however get some crazy overpowered armor and weapons though from the DLC, which you could then use in the main quest.
I bought this game after enjoying the demo a bit, and bought it for the full $15 on XBL. As soon as I go into the real game, the lobbies are constantly dead and the lag is absolutely awful.
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