I've just finished my first playthrough of Fallout: New Vegas, and I'll definitely play through it again since I missed out on many side quests, faction missions and companion quests. It was worth the price of purchase ($89.90 here in Australia, and give that our dollar is worth the same as the greenback, I'd say we're getting mighty ripped-off) from my perspective, however, there was one crippling issue that might make you fellow PC folk a bit hesitant to buy this game: 
 
FRAMERATE. 
 
I'm not really talking about bugs - in 25 hours of play, the game crashed once on me, and I only ever saw one serious bug (dog had it's eyeballs floating outside its head). Maybe it was because I played it after the patch, but I never saw any of the AI bugs, scripting bugs, quest bugs or item bugs that many others have commented on. Perhaps the PC version has less bugs than the Xbox version, I don't know.  
 
But one extremely crippling aspect of the game is its framerate. Anytime there were more than 3 NPCs on screen, the game stuttered and strained to process the action. It made some missions, particularly the last mission, very annoying. It was not due to my PC's specifications - it can run BFBC2 on its highest settings, with no problem. Maybe it was due to my drivers (ATI), but I haven't heard anything about it. And when I started the game up, it recommended the maximum graphical settings.  
 
The reason why I am raising this issue is that the Framerate can have a serious effect. I liked the True Iron sight mechanic in the game, and I used it frequently. Has a result, I did not take too many perks or invest much points into skills that raised my V.A.T.S efficiency. However, during the more hectic battles, particularly in the last part of the game, it was impossible to use anything other than V.A.T.S due to the crippling framerate.  
 
So to sum up this rather pointless post, if you've got the PC version of Fallout New Vegas, make sure to take every perk that improves V.A.T.S efficiency, and make sure you invest in the skills and attributes that will give you maximum AP. You'll have a much easier time as a result of it. 
 
Maybe it is due to my Drivers, but I don't think so. Maybe they are making a patch for it right now. But I find it hard to believe that they didn't notice this very serious problem before they shipped it. If they developed it primarily on a PC, they must know of the issues. The fact that they released the game in this state is very worrying, and very sad, since apart from this it is a stellar game and I encountered far fewer problems than most others. For instance, load times on the PC, for me, never lasted more than 6 seconds throughout the course of the game, and it only crashed once. 
 
But the framerate is a real killer. If you're one of those people who put FPS counters in the corners of their screens and obsesses over getting it above 60 FPS (like some people I know), steer clear until they fix it. 
 
For the record, I'm not saying F:NV is a bad game. It's plot, interweaving mission structure, characters, voice acting, art-design and theme are all of triple A standard. What I am saying, however, is that Obsidian have one hell of a lousy QA department, probably staffed entirely by howler monkeys and a brain-damaged parakeet.