Come on.  You know you like it quick and dirty.  On to the list. 
 
--New console based Suikodens and Wild ARMs: Two of my favorite RPG's from the PS1 and PS2 era have practically disappeared.  I wouldn't mind seeing new handheld versions of each, but please, if another Suikoden is brought to the handhelds, give us some interesting characters and castle-based mini-games and activities.  I really missed that in the latest iteration.  As far as Wild ARMs, I wouldn't mind seeing a reboot or a variation of the series featuring the classic gameplay, but I'd prefer a turn-based RPG in its classic vein. 
 
--New Tales of Monkey Island.  Come on, Telltale... you know you want to.  I'd also love to see them revisit Full Throttle and Grim Fandango, but I think that's just wishful thinking. 
 
--More info on Final Fantasy 13 Agito and Versus.  Pretty simpel stuff there. 
 
--New Final Fantasy Tactics.  Again, I'd prefer console, but hell, I'd take it on any system. 
 
--Sequel to inFamous. 
 
--New Nintendo games.  I never know what the hell team N is up to, but I'm always up for it (except for Wii Music - ugh).  Wouldn't mind seeing a new F-Zero. 
 
--More details, videos, and information on Diablo 3.  Hell,  I'll take any Diablo 3 tidbits I can get. 

--Fable 3 gameplay.  You know it's going to happen, but I'm still hotly anticipating it. 
 
What are yours?

I would love a new F-Zero. That would be on my wish list for Nintendo along with Mario Golf Wii, Mario Tennis Wii and Wave Race. I can't believe these games haven't even been considered.

I wouldn't hold your breath for a new Wild ARMs game, but it would be interesting to see where they'd take the series.  I think an inFamous sequel is pretty likely although I doubt an E3 announcement.

@RenegadeSaint:
Yeah, I'm not expecting anything except Wild ARMs re-releases for the next ten years or so.  I think it's a pretty dead franchise, unfortunately.  But hey, it's a list of my hopes, not necessarily my expectations.  Eh, what can you do? 

As far as inFamous 2, why not an E3 announcement?  It would make a great marquee game for the PS3 corner.  I'm also sort of expecting to read about an inFamous PSP game at some point, though I'm not sure I'd go for it.

I guess I was technically right about inFamous 2?  Although I was obviously implying they wouldn't announce until after E3, so for all intents, you were much more correct than I.  It will be interesting to hear the details as they emerge.