I had a really powerful character going into the fight against Satan with about 10 full hearts, and I had the Bible. I decided to use it to see if it had the same effect as it did against Mom, I didn't think there was a chance that it would work, but at least I would get the flying power-up.
Well, I used it, and much to my dismay, I was instantly killed, from full health to nothing. So, just a warning for you guys so you don't have to experience losing an hour or so of your time on a wasted playthrough.
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