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Euryale, in Greek mythology, was one of the two Immortal Gorgons, three sisters with brass hands, sharp fangs and hair of living, venomous snakes. She, like her sisters, was able to turn any creature to stone with her gaze. Her sister Stheno was also Immortal, but her other sister Medusa, was not.
Evila is one of the three secondary antagonists of the first Space Channel 5 video game. She is a robotic replica of Ulala, designed by Channel 5's chief, Blank, in order to copy and create The Ultimate Reporter. Her destruction, creation, and failure is what lead to the creation of the Evila Security Bots, which were tamed by Space Michael.
Excella Gionne is the head of the African branch of the TriCell Pharmaceutical Company. She has allied herself with Albert Wesker in Resident Evil 5.
The fanatical Shadow Druid of the Baldur's Gate series.
A misandrist Kryptonian serial killer and associate of General Zod.
A character in Lightning Warrior Raidy.
Character from the Lightning Warrior Raidy series.
A member of Dead Cell in Metal Gear Solid 2, Fortune is also known as 'Lady Luck'. She has lived a sad life.
Frau Engel is the sadistic commandant of the Belica Labor Camp in Wolfenstein: The New Order. She nearly kills B.J. Blazkowicz on multiple occasions.
Antagonist from the game "Nostalgia." She is a member of the Black Order.
Antagonist in the game Tengai Makyou II: Manjimaru. Member of the evil Root Clan.
Black Hand mercenary leader and secondary antagonist of Just Cause 4.
Gale is an evil bird and Stella's arch-nemesis in the Angry Birds series.
Captain of the Dark Athena and rogue mercenary. She is the main antagonist of the second part of Riddicks adventure called "Assault on Dark Athena".
Serpiente is one of Yaotl's generals.
One of the main antagonist from the Pac-Man franshice. She is in charge of the Ghosts.
Giant Evila is a giant robot controlled by Chief Blank to stop Ulala, Pudding, and Jaguar from finding the truth.
The Genetic Lifeform and Disk Operating System of the Aperture Science Enrichment Center in Portal. GLaDOS is a maniacal, rogue AI known for her disdain for humans and unintentionally humorous nature.
The final boss of Wario Land 4.
Golden Queen is a villain-turned-sensei in the Skylanders series.
Despite her name, there is no Goodness in Granny. She is Darkseid's right hand woman and the trainer of the Female Furies.
Gruntilda is a witch whose one act of profitable villainy has turned into an obsession with restoring herself and defeating Banjo. She often speaks in rhymes and favors a combination of magic, machinery and minion power in battle.
Antagonist in the game "Dengeki Nurse."
Hades Izanami is revealed to be the true antagonist of the Blazblue series and the one using Saya as her Vessel
The Harbinger, or the Harbinger of the truth, was a female Xalanyn who was active in the year 2560 during the Battle for Zeta Halo. The Harbinger was awoken from a Cylix by the Banished as they both sought to repair Zeta Halo in order to unleash the Endless.
Harleen Francis Quinzel is a former doctor at Arkham Asylum, and the Joker's accomplice and lover in the Batman universe. She is known for her Jester-like aesthetics, childish behaviour, and psychotic devotion to the Joker. She is best friends with Poison Ivy.
Hashladûn, Daughter of Crota (also known as the Inundated) is an Ascendant Hive Wizard.
Heather (Fingy in Japan) is a protaganist in the game Dynamite Headdy.
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