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Vertigo is a Primal Rage character who is a cross between a Tanystropheus dinosaur and a cobra. She is the goddess of insanity and one of the "destructive beasts." As she is the only female in the game, you'd think all the other characters would just fight over her rather than fight her.
Vezok was a Skakdi of Water and one of the seven rogue Dark Hunters who called themselves the Piraka.
Timmy's menacing babysitter and arch-enemy.
The Russian antagonist in Vanquish.
Victor Zakhaev is one of the main enemies in Call of Duty 4. As the son of primary antagonist Imran Zakhaev, he becomes a prime target of a joint operation by U.S. and British forces.
A Maverick Hunter turned Maverick working for Sigma.
Vince McMahon was the chairman of World Wrestling Entertainment (WWE) until 2022. He appears in many WWE video games.
The Vizier is a black-hearted government minister with grand plans to wrest power from the sultan and claim the young princess as his own.
Kingpin of the Volk, an eastern European militia organization.
A secondary antagonist in Modern Warfare 2, Vladimir Makarov takes centre-stage in Modern Warfare 3.
The chief CO of Black Hole. The mastermind behind all the dastardly plots against Omega Land in Advance Wars: Dual Strike.
Vosik, the Archpriest is the general of the Devil Splicers and second-in-command to Aksis, Archon Prime. He has the intention of ascending to godhood the way Aksis has, unless a team of Guardians kill him before it happens.
Primary antagonist of Half-Life 2 and a general betrayer of humanity.
Sheriff of Sinclair Parish with ties to the Southern Union.
A Chemistry teacher who manufactures crystal meth to support his family and to pay for his cancer treatment.
Walton Simons is the current director of FEMA, and a primary antagonist in Deus Ex.
Wamuu ("Wham") is a Pillar Man - one of four ancient vampire-like beings who vexed Joseph Joestar during the second chapter of JoJo's Bizarre Adventure.
The protagonist of Shadow of the Colossus.
This One piece character was the former ruler of the Drum Empire. He ate the Munch Munch fruit, which lets him eat just about everything and takes on the properties of whatever he eats.
Wario is Mario's rival and doppelganger; a crude garlic-loving brute with an obsession with treasure. Wario's name is a portmanteau of the word "warui" ('bad' in Japanese) "Mario".
Werdna is the evil wizard villain of the Wizardry series of games. His antithesis would be anyone named Andrew.
A renowned Austrian archaeologist and once mentor to Lara Croft. He is introduced in Tomb Raider: Revelations as the antagonist, due to a misunderstanding of events which take place in the prologue.
Enemy of Iron Man.
In the Marvel Universe, David Cannon has the mutant ability to spin his body rapidly, giving himself a whirlwind effect. He uses his power for his own gains.
A large apple tree from Kirby games. He is said to be very old and wise.
This villainess of Oz wants Dorothy's shoes so she can take over Oz. She has an aversion to water and wears black because that's the only color that goes with her skin.
The leader of the Corpse Brigade, a band of disgruntled common-born anarchist soldiers that strike out against the nobility for their unfair treatment after the Fifty Years' War of Ivalice. He joins the Templar Knights later on, believing their mysterious power is the answer to free society of the manipulative and exploitative aristocracy.
The supergenius coyote who can't seem to catch the Road Runner appears in several Warner Bros. games.
William Birkin is a former co-worker of Albert Wesker. He created the G-Virus and is partially responsible for the outbreak that destroyed Raccoon City.
A charismatic, ruthless leader of a community of survivors in Telltale Games' The Walking Dead: Season Two. Voiced by Michael Madsen.
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