Physical empowerment is the hallmark of any hero, but games have evolved to bestow on their main characters real world attributes. In the form of Fatigue, characters can display that they have exerted their energy and need rest.
Silent Hill 2
The Silent Hill 2 protagonist James Sunderland can run through Silent Hill but eventually slow to a jog. If the player stops after running for a while, James will pant to catch his breath. Additionally, Maria will also run and jog alongside James, but she also must rest to catch her breath.
Super Mario 64
In Super Mario 64, Mario will pant for breath each time he stops if his health has been reduced to two bars or less. A behavior not having to do with his health comes in the form of Mario remaining sedentary. If the player leaves Mario stationary for an extended period, he will sit down and fall asleep as an idle animation.
In Bully, Jimmy Hopkins becomes fatigued over the course of the day. As the in-game clock approaches late-night hours, Jimmy will start feeling drowsy, inhibiting his movement and altering his vision. At 2 AM, he will pass out regardless of his location.
Shin Megami Tensei: Persona 3
In all all versions of Persona 3, the main character and his allied party members can become fatigued while exploring Tartarus. The condition manifests after characters spend an extended period of time exploring the dungeon's halls and fighting numerous battles. Tired characters suffer penalties to their stats, and after each battle will make a comment in context of their exhaustion. When characters become tired, they will automatically leave the party if the player returns to the Tartarus lobby, and if the main character is in this condition, returning to the lobby will bring an end to the night's expedition. Characters may require more than one day to overcome fatigue.
Kid Icarus: Uprising
During the ground portions of Kid Icarus: Uprising, Pit will start to sweat if he runs at full speed for an extended period of time. If the player does not stop, he will eventually slow down and be forced to stop in order to catch his breath.