Nope.
Speculations and potential spoilers ahead.
I accepted the fact that Bethesda Softworks' and 3D Fallout games' stories were all over the place a long time ago. I can appreciate both the 2D CRPG and 3D FPS/RPG games for what they are but I Here's my two cents on what little I've seen via the leaks and promotional material.
The world looks like a larger and similarly dense analog of the past two Fallouts' demonstrating new technologies, factions and architecture than the previous games. I've never been to Boston myself so I can't speak to cultural authenticity but the virtual equivalent at least looks like it has its own voice distinct from that of D.C, New Vegas and even the first Fallout games. It sounds huge as well, I just hope there's enough density in locations since I haven't seen many locations and the ones I've seen are without context.
The assets themselves have more detail because Bethesda's approach to AAA development on their main franchise tends to involve iterative improvements on that. It may not look like that's happening to some but it's something that's hard to show without high-quality screenshots or gameplay footage. The graphical complexity, UI/UX, animations and overall visuals aren't bleeding-edge but it's way closer to same considering the base of the game engine dates back to the 90s. More importantly, they're authentic to the aesthetics of the 3D franchise. The voice acting and simplified Mass Effect-esque speech system will be divisive but I enjoyed the Mass Effect approach to things. I don't think it's necessarily as appropriate to Fallout as seeing the entire line of dialogue presented but that could be fear of change. I don't dislike the choice of a voiced protagonist but I do look forward to the inevitable dialogue throwback mod for roleplaying.
I haven't seen much of the story as I don't have a review copy, so what I have seen (part of the opening prologue, a couple of other missions later, all part of leaks) seems consistent with Bethesda's writing and direction in the past, the major difference being that a lot more dialogue is being run through in real-time (including contextual voiceover narration) instead of the FO3/NV method of pausing the game and interacting only with the target of the conversation (something Skyrim also enjoyed to a less flexible extent).
Haven't seen too many awful bugs/immersion-breaking quirks (besides Dogmeat giving no fucks about gravity or being on fire) but I suspect there'll be plenty. My observation is that the Creation Engine's generally more stable than Gamebryo for me, so I presume there's probably less of the jank that plagued FO3/NV but not none. Again, mod support probably might help with stability. (A rare thing to get official developer/publisher support on in AAA, I might add.)
The music selection I'm curious about. It seems that alongside the usual classic licensed music that Bethsoft elected to have lyrical music written for the game on top of its background score. I trust in Lynda Carter's good name even though I'm not really sold on the song I've heard on SoundCloud. We'll see how well it fits the atmosphere the 3D games have usually had. I also kinda hope that Erik Todd Dellums (rumored at one point to be involved in FO4) has at least a cameo but I haven't heard much of anything about that of late.
The Pip-Boy's got a smaller screen size, which may be problematic UX-wise but its new features (collectable holotapes, RGB customizable UI elements, redesign for right-handed manipulation and animation and overall higher-resolution texture work) seem like a pretty great idea thus far. I don't know if it's like the new VATS in the sense that the game doesn't pause when the Pip-Boy's activated but if that's the case it should be interesting to see the ramifications of something similar to what was used in MGS V: The Phantom Pain.
The combat mechanics look vastly better than they did for Fallout 3. I understand the die-roll hit chance thing that Bethsoft was going for initially, but nowadays, I feel like there was a confict of interest between wanting to preserve the random chance of RPG combat and wanting first-person world immersion through dynamic combat. The combat here seems augmented by perks but mostly dependent on FPS ray-tracing (or whatever's used for determining successful shots these days) as opposed to FO3/NV where it was a combination of that offset by random unavoidable failure. I'm super excited for this, although it makes it seem like the game is more of an FPS with RPG elements now and that it has less in common with its predecessors.
Customization I know little about, but I'm one of those who will find themselves hopelessly lost in that meta-game between story missions, trying to make an office building and business hegemony spanning the wasteland at the first available opportunity.
TL;DR: I'm not really nervous, there's more than enough in the world and general vibe of the game to convince me it's a Fallout title while also changing up a lot of things in interesting (and hopefully beneficial) ways.
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