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Rhino is a nemesis of Spider-Man. His costume gives him superhuman durability and strength.
Spider-Man villain often associated with Spider-Slayers, along with his father, Spencer Smythe.
Adam Brashear is a walking anti-matter reactor. This makes him one of the most powerful heroes on earth, as the Blue Marvel.
The Carnage symbiote is the offspring of the Venom symbiote. Cletus Kassidy is the main host for the Carnage symbiote but it has bounded with others over the years.
The Chameleon is actually one of Spider-man's earliest super-villains. A master impersonator, he uses his costumes for villainy and fun.
Doctor Doom is a supervillain from the Marvel Universe who is bent on world domination. He is the ruler of Latveria and the primary antagonist of the Fantastic Four.
Ex Nihilo is a Gardner, a member of a species created by a tribe called the "Builders", to flash-evolve beings into perfect evolutions of themselves.
The Sandman, also known as Flint Marko or William Baker, is a Marvel Comics character and a regular enemy of Spider-Man. He has occasionally been a superhero, and even briefly was a reserve member of the Avengers.
Grey Gargoyle is from the Marvel Comics universe. He was a French chemist who developed his powers by spilling an unknown chemical mixture on himself.
The Kingpin, aka Wilson Fisk, is the biggest crime lord in New York City, and possibly the world. He operates under the guise of a legitimate businessman and philanthropist, much to the chagrin of Spider-Man, Daredevil, and the Punisher.
Lady Spider is a steampunk superhero from the year 1895.
Scorpion is a nemesis of Spider-Man. He was once private investigator Mac Gargan, until J. Jonah Jameson hired him to be the subject of an experiment that gave him immense strength, a costume with a tail that fires lasers, and the deep-down crazies. He was the third Venom.
Electro is a primary nemesis of Spider-Man. He has the ability to generate up to one million volts of electricity.
Spider-Man's beloved aunt, May Parker.
Miles Morales is the new Ultimate Spider-Man, after Peter Parker died in a shark-jumping battle with the Green Goblin. He has almost the same exact powers as Peter Parker, plus bioelectricity and invisibility.
After Quentin Beck went missing, his Mysterio gear was auctioned off to a random criminal, who began calling himself Mysterion.
The Green Goblin is Norman Osborn, a businessman and scientist who injected himself with an experimental serum to test it. The serum granted him immense strength, but also drove him insane. He is considered the arch nemesis of Spiderman. He is known for using his glider and pumpkin bombs.
A criminal Juggler who most often faces Captain America. Formerly of the Death-Throws, an entire team of criminal jugglers. Yes, really.
After being bitten by a radioactive spider during a science exhibit unrelated to school, timid teenager Peter Parker becomes the Amazing Spider-Man. Armed with the ability to climb walls and enhanced strength, Spider-Man uses his powers to fight evil and protect the innocent.
Monica Rambeau is a police officer-turned superheroine who has used many monikers including Captain Marvel, Photon, and Spectrum.
Former criminal, turned hero, often associated with Spider-Man.
Mysterio is a villain from Marvel Comics. He is specifically Spider-Man's enemy. He is recognized by his large fishbowl helmet and his use of illusion. He was portrayed by Jake Gyllenhaal in Spider-Man: Far From Home (2019).
Rosalie Octavius is Otto Octavius’ wife.
With a terrible track record, a costume resembling a soiled mattress, and a name that inspires fear for all the wrong reasons, the Shocker is primarily a laughingstock. This Spider-Man villain has gauntlets that allow him to generate powerful shockwaves.
One of the playable characters in Spider-Man Unlimited.
Spider-Girl is a character from the Marvel Comics universe (MC2). She is the daughter of Peter Parker and Mary Jane Watson.
Miguel O'Hara was injected with an addictive drug that would kill him if he didn't work for the company supplying that drug. He tried to cure his addiction by purifying his system on a molecular level but was sabotaged and accidently given spider-like abilities.
Charlotte Witter was the granddaughter of Madame Web, and an evil Spider-Woman created by Dr. Octopus.
Spot is a Spider-Man villain with portal powers.
Vincent Stegron was a SHIELD scientist who, appropriately enough, turned himself into a stegosaurus man.
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