Damn, I've been out of the loop for a straight minute... I didn't even know they were making a new Mass Effect.
I hope it's not a sequel that's for damn sure. Much like the Halo universe, I think it should have ended after the third installment in the trilogy. That being said, the Mass Effect universe is cool as hell so a game centered in that universe wouldn't be so bad, as long as they don't try to continue the story of the trilogy.