Nope. For me to be offended, it would have to be a personal attack on me or somebody I care for. I might find something "offensive", but that's a whole other animal. For example, I find the game "Ethnic Cleansing" horrendously offensive and disgusting. But I'm not personally "offended" by it, no matter how badly I want to punch the people who made it.
The whole point of South Park is to get under as many people's skins as possible without actually passing any real judgment on any of them. That's why Parker & Stone get away with material that nobody else can. They've made their intentions crystal clear, and at the end of the day it's about laughing at humanity as a whole, one group at a time. You're supposed to be offended. The trick is to say "Well, WHY does this offend me?", and then laugh at the absurdity of being offended by select things and not others in the first place.
It's not a perfect system, of course. I think the Muhammad episode was a bit foolhardy considering modern tensions, for instance, but for the most part it works.
I found the abortion clinic scene in the game to be hugely uncomfortable, but I knew that that's what I was in for, and I enjoyed having my own morality being challenged in a non-harmful way. (also, Butters' "It's a Holocaust in here!" had me rolling with laughter. So wonderfully over-the-top.)
By all means, if you're not cool with seeing the content in the game, there's nothing wrong with that. But don't act like you didn't know what you bought into, or imply that anybody who enjoys the game/show is somehow less refined than you.