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"4X" style games such as the Masters of Orion series or Galactic Civilizations have stations of various types, including scientific research facilities for aiding the player in progressing through a science and technology tree. Smaller versions of stations were used as outposts to extend one's territorial influences.
The space-based MMO EVE Online uses stations extensively for ship maintenance, market sales, research, and corporation hangars, as well as NPC and mission interaction.
The space station The Citadel in Mass Effect was featured prominently for a large part of the introductory game, and served as a hub for trade and story development throughout the game.