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Morpha is the boss of the water temple from The Legend of Zelda Ocarina of Time.
It's a giant sea eel! It has an eye in its mouth. How curious.
A B.O.W. created by Umbrella and featured in Resident Evil Outbreak File 2. It can absorb anything it can grab onto, including a Tyrant.
The hardest boss in Metroid Prime, the Omega Pirate is a Space Pirate that was genetically mutated by intense exposure to Phazon.
The first boss in Metroid Prime, Samus Aran faces this creature on board the Space Pirate Frigate Orpheon. Also makes a cameo in Super Smash Bros: Brawl
Pharaoh Walker is a giant automaton-sphinx and serves as the mid-boss villain in Power Stone 2.
Japanese boxer in the game Mike Tyson's Punch Out!! for the NES.
A giant puppet boss controlled by Ganondorf. He is similar in appearance to the beast form of Ganon. He has 3 different forms, Beast, Spider, and Snake.
A story-related boss in the game Borderlands. It is one of the largest bosses in the game.
One of the most iconic characters in the Metroid series. He is the Space Pirate general, and a recurring boss in the series. Ridley is Samus's arch-nemesis, and killed her parents when she was very young.
The main villain in Wario land 3 who manipulates Wario into releasing him from his seal. He also appears in Dr. Mario 64.
The king of reincarnated skeletons. He's pretty huge.
Thardus was the result of Space Pirate testing of the effects of Phazon on inanimate objects. He is the boss of Phendrana Drifts in Metroid Prime
The final boss of Borderlands. It dwells within the vault on Pandora.
A lizard-like creature that can scale vertical walls in Shadow of the Colossus.
A fierce golem with a fear of flames in Shadow of the Colossus.
A cleaver-wielding giant that guards a fortress in Shadow of the Colossus.
A large flying golem perched above a flooded ruin in Shadow of the Colossus.
The player's first target in Shadow of the Colossus.
A canid-like golem that guards an ancient city in Shadow of the Colossus.
The guardian of a verdant burial mound in Shadow of the Colossus.
Giant crab-like insect. The second boss you face as War in Darksiders.
The Hive Mind is a gigantic sentient being on the planet Aegis 7. It is the apparent origin of the Necromorphs and controls all Necromorph underlings telepathically.
Mannimarco, the King of Worms, is the grand potentate and de facto leader of the rebelling Necromancers. He is in direct opposition to the Mages Guild doctrines.
The final boss of the original Half-Life, the Nihilanth commanded the enslaved armies of Xen in an invasion of Earth.
A titanic tortoise-like golem shrouded by steam in Shadow of the Colossus.
A gigantic quadrupedal golem resembling a mammoth in Shadow of the Colossus.
A giant eel-like creature residing in a deep lake in Shadow of the Colossus.
Wander's final foe in Shadow of the Colossus.
A bearded giant that guards an underground temple in Shadow of the Colossus.
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