Initially released as Panel De Pon (パネルでポン) in Japan for the Super Famicom, the Puzzle League series is based around a match-three puzzle game. The gameplay involves matching panels of three or more by manipulating a cursor that will horizontally swap any two panels the cursor is placed over. It is similar in gameplay to games such as Yoshi's Cookie and Meteos.
Similar to the Puyo Puyo franchise, the series often has its graphical assets reskinned when released in western markets. The localized release for the Super Nintendo, Tetris Attack, was released as part of the Tetris franchise in North America, despite having nothing to do with Tetris. Much like Tetris Attack, the next two games to see release in the west were Pokémon-themed games (Pokémon Puzzle League & Pokemon Puzzle Challenge). It wasn't until the Nintendo DS release (Planet Puzzle League) that Puzzle League branding had been established for the franchise.