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An unknown Delvadian man took the mantle of Devil Spider after Roderick Kingsley.
The Chameleon is actually one of Spider-man's earliest super-villains. A master impersonator, he uses his costumes for villainy and fun.
Serena Patel heads the Shadow Division of Alchemax in a Marvel Universe based in 2099.
A six-armed copy of Spider-Man created during the Infinity War.
A brilliant scientist who specializes in electricity. She was created especially for the game Spider-Man 2: Enter Electro.
Dusk is a superhero in the Marvel universe. Originally, the Dusk persona and costume were a disguise for Spider-Man, but were later taken up by Cassie St. Commons.
Eddie Brock is a character in the Marvel Universe best known as Venom. He became Venom when he joined with an alien symbiote life form and was one of the most fearsome enemies of Spider-Man. He has also use the Anti-Venom and Toxin symbiotes at different points in his life.
The father of the Spider-Man enemy best known as Venom, Eddie Brock.
Felicity Hardy is the daughter of Felicia Hardy and Flash Thompson, and the Scarlet Spider of the MC2 universe.
Firestar (Angelica "Angel" Jones) is a fictional mutant superhero in the Marvel Comics universe. She has the ability to generate and manipulate microwave radiation, which allows her to generate intense heat and flames and to fly.
Known for bullying Peter Parker in his high school years, Flash is one of the original Spider-Man characters. For a period of time he was Agent Venom.
The Sandman, also known as Flint Marko or William Baker, is a Marvel Comics character and a regular enemy of Spider-Man. He has occasionally been a superhero, and even briefly was a reserve member of the Avengers.
A dangerous android who mimics the powers of Spider-Man and Venom.
Spider-Man from a reality where he gained power similar to Ghost Rider on top of his spider powers.
A mysterious villain from the year 2099 who has taken on the Goblin tradition.
Gabriel Stacy, the son of Norman Osborn and Gwen Stacy, became the insane Grey (or Gray) Goblin.
One of Spider-Man's first girlfriends. In some universes, she is also known as Spider-Gwen. She has been portrayed by Bryce Dallas Howard, Emma Stone and Hailee Steinfeld in various films.
Spider-Man villain.
Tony Stark's employee and best friend.
Harry Osborn was Peter Parker's best friend. He became the second Green Goblin after finding out Peter Parker was Spider-Man, who he thought was responsible for his father's death.
Manhattan district attorney rescued from Iguana by Spider-Man.
The Hobgoblin is a Spider-Man villain. Roderick Kingsley, a fashion designer with connections to the criminal underworld, became the Hobgoblin when he discovered a cache of weapons and a glider left by the Green Goblin.
Mysterious Goblin-inspired enemy of Spider-Man 2099. It is thought, though not proven, that he was created from DNA of one or more Goblins who challenged Peter Parker during the Heroic Age.
Hornet is a superhero in the Marvel universe. Originally, the Hornet persona and costume were a disguise for Spider-Man, but were later taken up by Eddie McDonough.
Spider-Man villain with Hydrokinesis (the ability to control water), often part of teams with vendettas against the wall-crawler.
Humanoid iguana who is an enemy of Spider-Man.
A Japanese fairy-tale version of Spider-Man
The editor-in-chief of the Daily Bugle in Spider-Man games. Has an agenda against the wall-crawler. He is portrayed by J.K. Simmons in the Sam Raimi Spider-Man Trilogy and the Marvel Cinematic Universe.
Father of J. Jonah Jameson of Daily Bugle fame, Jameson Sr. is married to Peter Parker's Aunt May in current Marvel Comics continuity.
Mad scientist and enemy of Spider-Man who specializes in cloning.
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