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A reconnaissance Reaper serving as a vanguard, attempting to summon an entire Reaper fleet to wipe out all organic life every fifty thousand years.
Specter is a monkey that made his appearence in ape escape as a boss and is the leader of the apes.
Spiral is a henchman for Mojo. She has teleportation powers, and six arms.
Sportsmaster is a villain in the DC Universe.
The leader of the Peach Mountain Shoguns from Mystical Ninja Starring Goemon. He wants to turn all of Japan into a stage for the biggest musical ever.
One of Rita Repulsa (and later, Lord Zedd)'s bumbling henchmen.
Squishy is the squid from the Kirby games. Beware the tentacles!
Carol Ferris is the oft-love interest, sometime enemy, and sometime ally, of Hal Jordan the Green Lantern.
Starscream is a recurring character in the Transformers franchise. His position as second-in-command and loyalty to Megatron (feigned or sincere) are definitive aspects of the character. He often takes on the form of a jet or a combat aircraft of some kind.
The Stay-Puft Marshmallow Man threatens New York with sweet sugary destruction in the original Ghostbusters.
Stephanie McMahon is the daughter of WWE Chairman Vince McMahon and occasionally a professional wrestler and valet. She appears in many WWE games.
A psychopath from the original Dead Rising and Dead Rising: Chop 'Till you Drop. He doesn't allow vandalism in his store.
Stewart Gilligan Griffin, more commonly known by his nickname "Stewie", is a fictional character in the animated series Family Guy. He is also a genius 1 year old and is thought to be bisexual. He has plans to take over the world and kill his mother.
Stilt-Man is generally a laughing-stock in the villainous community. He hates both Daredevil, and Spider-Man
One of the main antagonists of Toy Story 2.
Some might call him an evil alien robot with a kickass CO power, but others just call him Sturm. He is the main villain of the first two Advance Wars games.
Sugar Man is a grotesque villain from the alternate "Age of Apocalypse" earth.
Suigintou is the first Rozen Maiden doll. She is very brutal in her methods and hates Shinku the most.
Sumo Kong is a boss in Donkey Kong Jungle Beat. He is the ruler of the Star Fruit Kingdom.
Another GT villain made with Android 17 merging with another #17 from the depths of Hell.
Supergiant is Thanos' psychic enforcer
Supreme Leader Snoke was the founder of the First Order and mentor of Kylo Ren. He is the secondary antagonist of the Star Wars sequel trilogy.
Susano'o is the true vessel of main antagonist, Terumi. who appears in Central Fiction
The main antagonist of Lollipop Chainsaw who is an evil goth druid, whose goal is to break the barrier between the human world and the Rotten World, a world inhabited by zombies and other demonic forces.
Swiper is a blue masked and gloved fox from the Nickelodeon show Dora the Explorer. As his name applies, he likes to steal but can be prevented from swiping if someone says "Swiper no swiping!" three times.
Sylvester the Cat is one of the main characters in the Loony Tunes cartoon series.
The Final Gt Villain and the most powerful of all the shadow dragons he absorbs them into Omega Shenron.
Syndrome is an enemy of the Incredibles.
The T-1000 is an android assassin sent by Skynet to kill John Connor in 1995. He is made from a type of liquid metal and has the ability to shape shift.
Caulder's oldest daughter from Advance Wars: Days of Ruin. Believes she's clearly superior than everyone else and thinks nothing of crushing people beneath her feet.
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