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A traitor and enemy to the vast majority of Resident Evil's protagonists, Albert Wesker has rapidly achieved super-villain status within the series canon.
An Umbrella researcher, Annette is the wife of fellow researcher William Birkin to which they have a single child, Sherry Birkin.
One of the playable U.S.S. (Umbrella Security Services) characters in Resident Evil: Operation Raccoon City, Beltway is the demolitions expert.
Bertha acts as the medic for Delta Team of the U.S.S. (Umbrella Security Service) from Resident Evil: Operation Raccoon City. She has a fondness for medicine and a greater appreciation for pain.
Mendez is the village chief in the first area of Resident Evil 4. He warns Leon of the power of the Las Plagas and later tries to kill him.
The primaryantagonist during Leon S. Kennedy's campaign in Resident Evil 6, and the reason for the events across the entire game.
One of the playable U.S.S. agents in Operation Raccoon City, Four Eyes is a Virologist of Umbrella Security Services team 'Wolfpack'.
Jack Krauser is one of the antagonists in Resident Evil 4. He is very skilled in knife fighting and archery. A former partner of Leon S. Kennedy, Krauser considers himself Leon's main rival.
Villain in Operation Javier Scenario of Resident Evil: The Darkside Chronicles
Leader of Umbrella Security Service unit "Wolfpack" from Resident Evil: Operation Raccoon City. Voiced by Nikka Futterman.
Osmund Saddler plays the role of the main antagonist in Resident Evil 4. He is the leader of the religious cult Los Illuminados.
Ramon Salazar is one of the main antagonists in the game Resident Evil 4. He runs the castle mid-game and has a small stature.
One of the playable U.S.S (Umbrella Security Services) characters in Resident Evil: Operation Raccoon City.
U3 is a creature sent by Osmund Saddler in an attempt to kill Leon S. Kennedy. U3 is also referred to as "It".
A B.O.W. programmed by Neo-Umbrella to hunt down Jake Muller.
One of the playable U.S.S. (Umbrella Security Service) characters in Resident Evil: Operation Raccoon City.
The Verdugo (which is spanish for Executioner) is a sub-boss in the game, Resident Evil 4. They also serve as Ramon Salazar's body guards. He is one of the few bosses in the game that Leon doesn't have to defeat.
William Birkin is a former co-worker of Albert Wesker. He created the G-Virus and is partially responsible for the outbreak that destroyed Raccoon City.
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