What exactly do you mean? What quests can't be done after after the credits roll or what quests would we recommended before you put the game down for good?
I'm pretty sure only the companion quests are lost post credits. If you're looking for insight into the better quests in the game I recommend you do each region's main quest line, since those tend to be the most involved and interesting.
These are ones like the Tomb of Fairel for the Hissing Wastes, clearing the quarry and reclaiming the keep in Emprise du Lion, helping Fairbanks and his group in the Emerald Graves, and just generally speaking seeing through the quest chain that is kicked off when you first enter a region. I also recommend killing all ten Dragons, they're the best combat encounters in the game if you're not too overleved (the level 23 Dragon in Emprise du Lion was a tense and lengthy battle, tons of fun).
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