Female = Miranda from mass effect 2, chloe and elena from uncharted. Lightning from FF13. Elizabeth from Bioshock infinite.
Generated = The Boss from saints row. Shepherd from Mass effect, Your dark souls guy/girl.
Male = Asura from Asuras wrath. Ezio from assassins creed. Old Altair from Assassins creed revelations, Geralt from the Witcher 2. Nathan Drake from uncharted, Niko Belic from gta 4, Michael De Santa, Trevor Philips, and Franklin from GTA5, John Marston from Red Dead redemption.
id list more, but looking through some of the submissions here, people got it nailed.
has to be mass effect 2, that singular raw experience of gathering your guys building a relationship with your crew, and going to fight the greater evil and then flying out of that collector base with everyone alive is one of the best moments in entertainment history.
its all the more reason and testament to this game why mass effect 3 was a letdown and the enormous backlash 3 had.