Not to mention the potential ramifications for sites like Giantbomb whose entire content schedule is based around the idea of playing a video game and talking over it. This whole thing is a really slippery slope, so regardless of whether or not you agree with this move, you should be worried that Nintendo is willing to do this.
This is what we should be talking about, really. GB's content isn't really that different from that of some of these LPers, except that they're not advertising (I think?) on YouTube. Where is the line drawn between two separate instances of people talking over video game footage for money?