I just finished my first playthrough as an adept on hardcore which I thought I'd mention just because no one has said anything about adept yet - but I decided on Vanguard for insanity, using Reave as extra power. So far I'm finding it's a lot different than adept, which is a good thing.
I hate to do another biotic class - I did a full playthrough as an engineer in mass effect and enjoyed it, but I just don't like the idea of combat drone or tactical cloak at all. And soldier is a little too vanilla for me. Sentinel seems to be the defacto easymode class, so here we are with the Vanguard.
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