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Also known as the Priest in the Assassin's Creed: Brotherhood multiplayer mode, Brother Ristoro is a brother of the Order of the Minims and an assassin for the Templars.
A French Templar from the Renaissance who committed murders dresses as a Hellequin
A French templar who operated during the Renaissance era, dressed as a colorful harlequin.
A Courtesan who does work for Cesare Borgia
Also known as the Executioner in the Assassin's Creed: Brotherhood multiplayer, Il Carnefice is an ally for the Borgia and a brutal assassin for the Templars.
The daughter in-law of Rodrigo Borgia, and spouse of Cesare Rodrigo. She is one of the antagonists of Assassin's Creed: Brotherhood.
A serial killer also known as The Doctor from Assassin's Creed: Brotherhood. He's a target in sequence four as well as a playable character in multiplayer.
Also known as Pope Alexander VI or 'The Spaniard'. He is the main antagonist in Assassin's Creed 2
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