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As the leader of the Nazis, Adolf Hitler has appeared as an antagonist in several video games. Commonly considered the worst person ever, if you get the chance to kill him, you probably should.
Rhino is a nemesis of Spider-Man. His costume gives him superhuman durability and strength.
Apocalypse is a mutant who is over 5000 years old. He believes strongly in "the survival of the fittest." He was portrayed by Oscar Issac in the 2016 film X-Men: Apocalypse.
Arcade is a supervillain/hitman in the Marvel Universe. He assassinates his victims by kidnapping them and setting them loose in a maze of deathtraps disguised as an amusement park called Murderworld.
One of Mister Sinister's Marauders in the Marvel Universe, Arclight creates seismic waves and boasts incredible strength enabling her to lift 50 tons.
Aurora is a member of Alpha Flight and is very close to her brother, Northstar.
Banshee is a mutant who started as a villain, but later became a member of the X-Men. He can fly and has the ability to attack by shouting.
Black Tom Cassidy is the evil cousin of Banshee.
The son of Mephisto, the Devil, Blackheart is a powerful demon who wishes to overthrow his father as Lord of Hell.
One of Mister Sinister's Marauders in the Marvel Universe. He's very strong and resistant to physical injury.
Bullseye is a supervillain from the Marvel Comics universe. He holds a serious grudge with the blind superhero Daredevil, and is one of his two arch-enemies (the other being Kingpin).
Carol Danvers is a superhero in Marvel Comics, currently known as Captain Marvel. She is half human and half Kree, one of the alien species of the Marvel Universe.
A doppelganger of Spider-Man created by Doctor Doom after he gained Odin's powers
Deathstroke, also known as Slade, is a character that has appeared in many various comic books as a super villain, most notably Teen Titans. He has also appeared in the Teen Titans video game.
Doctor Doom is a supervillain from the Marvel Universe who is bent on world domination. He is the ruler of Latveria and the primary antagonist of the Fantastic Four.
An absurdist Marvel character
Galactus is the devourer of worlds. He is nearly omnipotent.
A Japanese macaque assassin.
Holocaust is the son of Apocalypse in the Age of Apocalypse universe.
The Juggernaut is the stepbrother of Professor X. He gains his powers from a gem that allows him to become unstoppable.
The Kingpin, aka Wilson Fisk, is the biggest crime lord in New York City, and possibly the world. He operates under the guise of a legitimate businessman and philanthropist, much to the chagrin of Spider-Man, Daredevil, and the Punisher.
Kraven, the world's greatest hunter, is obsessed with killing Spider-Man, whom he views as the ultimate prey.
Norse God of Mischief, Brother of Thor, Odinson.
The King of Pop, Michael Jackson was a successful American recording artist and has made an appearance in at least eight video games.
Moon Knight is Marc Spector after the Moon God Khonshu resurrects him. Trained as a mercenary and boxer with enhanced strength. At night, Moon Knight is a force to be reckoned with.
Nick Fury, Jr. is the son of the famous agent of S.H.I.E.L.D. He was designed to emulate the Ultimate universe/Cinematic Universe version of Nick Fury.
The Green Goblin is Norman Osborn, a businessman and scientist who injected himself with an experimental serum to test it. The serum granted him immense strength, but also drove him insane. He is considered the arch nemesis of Spiderman. He is known for using his glider and pumpkin bombs.
Northstar is a speed based mutant associated with the X-Men and Alpha Flight.
Doctor Otto Octavius was a scientist who turned to a life of crime, using a set of four flexible mechanical arms originally designed to assist in scientific research and labwork to give himself a major advantage over the police.
Deadpool tried to kill Spiderman on his TV show "Pain Factor"
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