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HYDRA's resident evil psychiatrist.
Norman Osborn's personal assistant.
A six-armed copy of Spider-Man created during the Infinity War.
Dormammu is a character from the Marvel Universe. He was once a human wizard from an alternate dimension, but soon conquered the Dark Dimension and gained unmatched mystical power.
Werewolf who opposes Spider-Man.
Francine Frye was an obsessive supervillain fangirl who became the second Electro.
An evil clone of Daredevil from the Marvel Universe.
An evil clone of the Hulk from the Marvel Universe.
An evil clone of Vision from the Marvel Universe.
An evil clone of Wolverine from "Marvel Superheroes in War of the Gems".
Fixer is a technical genius who will sell his inventions to anybody who will pay, regardless of alignment or morality.
The Sandman, also known as Flint Marko or William Baker, is a Marvel Comics character and a regular enemy of Spider-Man. He has occasionally been a superhero, and even briefly was a reserve member of the Avengers.
Galactus is the devourer of worlds. He is nearly omnipotent.
One of Iron Man's Iron Legion who rebelled under Ultron's command, but after the latter's defeat, wound up hanging out with other former enemy agents at the Avengers Academy compound.
Grey Gargoyle is from the Marvel Comics universe. He was a French chemist who developed his powers by spilling an unknown chemical mixture on himself.
Gabriel Stacy, the son of Norman Osborn and Gwen Stacy, became the insane Grey (or Gray) Goblin.
Spider-Man villain.
Harry Osborn was Peter Parker's best friend. He became the second Green Goblin after finding out Peter Parker was Spider-Man, who he thought was responsible for his father's death.
A Japanese macaque assassin.
The Hobgoblin is a Spider-Man villain. Roderick Kingsley, a fashion designer with connections to the criminal underworld, became the Hobgoblin when he discovered a cache of weapons and a glider left by the Green Goblin.
Spider-Man villain with Hydrokinesis (the ability to control water), often part of teams with vendettas against the wall-crawler.
Humanoid iguana who is an enemy of Spider-Man.
The editor-in-chief of the Daily Bugle in Spider-Man games. Has an agenda against the wall-crawler. He is portrayed by J.K. Simmons in the Sam Raimi Spider-Man Trilogy and the Marvel Cinematic Universe.
Billy "The Beaut" Rosso is one of the Punisher's biggest enemies. He became Jigsaw after The Punisher disfigured his face.
Johnny Ohm was a criminal formerly on death row, who survived the electric chair. Niles Van Roekel turned him into an Imperfect by giving him the power to manipulate and generate electricity.
The Juggernaut is the stepbrother of Professor X. He gains his powers from a gem that allows him to become unstoppable.
Kaine is one of the many clones of Spider-Man. He was a noted serial killer until he was resurrected during the events of Spider-Island. Afterwards he turned over a new leaf and became the new Scarlet Spider.
Karn is a member of the Inheritors, a family of otherworldly beings who hunt down "totems" - people who represent specific members of the animal kingdom.
The Kingpin, aka Wilson Fisk, is the biggest crime lord in New York City, and possibly the world. He operates under the guise of a legitimate businessman and philanthropist, much to the chagrin of Spider-Man, Daredevil, and the Punisher.
The fusion of Ultron of Earth-5468 and Wilson Fisk ("Kingpin")
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