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Aaron Davis, the uncle of Miles Morales who was secretly the costumed thief known as Prowler in the Ultimate Universe. For a time, he also took the identity of the Iron Spider.
Abyss is the final boss in Marvel vs Capcom 2. He has three forms including a giant black statue man, a green ghost-like man, and a giant lava monster.
Vulture is a villain in Marvel Comic's Spider-Man Series. Adrian Toomes created the flight suit and became the Vulture.
A spider god in Mochica culture. He became the second Dark Spider-Man in Marvel Comics.
Rhino is a nemesis of Spider-Man. His costume gives him superhuman durability and strength.
Spider-Man villain often associated with Spider-Slayers, along with his father, Spencer Smythe.
An in-universe rip-off of Spider-Man in a movie that was being filmed.
Arcade is a supervillain/hitman in the Marvel Universe. He assassinates his victims by kidnapping them and setting them loose in a maze of deathtraps disguised as an amusement park called Murderworld.
Mysterious, seemingly mindless enemy who pursues Spider-Man in Spider-Man: Edge of Time. It is an accidental fusion of Doctor Octopus and Anti-Venom.
Attuma, a villain featured in Marvel: Ultimate Alliance. Primarily a Namor villain, he teams up with Doom's Masters Of Evil.
Big Wheel is an enemy in the Spider-Man universe and is featured in the game Spider-Man: Mysterio's Menace.
Genetically altered clone of Black Cat. She has all of Felicia Hardy's memories...and feelings for Spider-Man.
Carlos LaMuerto is the latest in a 700-year old line of Argentinian crimelords taking the name Black Tarantula.
The son of Mephisto, the Devil, Blackheart is a powerful demon who wishes to overthrow his father as Lord of Hell.
Blood Spider was a disciple of Taskmaster designed to mimic and oppose Spider-Man.
Member of the Jury, determined to bring down Venom, archenemy of Spider-Man.
In the Spider-Man movie universe, Bonesaw was Spider-Man's wrestling opponent, before Peter Parker became a super hero.
Bullseye is a supervillain from the Marvel Comics universe. He holds a serious grudge with the blind superhero Daredevil, and is one of his two arch-enemies (the other being Kingpin).
The killer of Spider-Man's Uncle Ben.
An enemy of Spider-Man, she's a voodoo priestess who constantly brings herself back to life.
A merging of the Carnage and Venom symbiotes, created specifically for Lego Marvel Super Heroes 2.
The Carnage symbiote is the offspring of the Venom symbiote. Cletus Kassidy is the main host for the Carnage symbiote but it has bounded with others over the years.
Dr. Curt Connors is a scientist in the Marvel Universe who transforms into the vile Lizard, usually fighting Spider-Man.
A doppelganger of Captain America created by Doctor Doom after he got Odin's powers
A doppelganger of Spider-Man created by Doctor Doom after he gained Odin's powers
Deadpool tried to kill Spiderman on his TV show "Pain Factor"
The third Hobgoblin (Jason Macendale) became possessed by a demon after making a deal with N'Astirh. When Jason rid himself of the demon, the demon became Demogoblin. Ally of Carnage, enemy of Spider-Man and Venom.
An unknown Delvadian man took the mantle of Devil Spider after Roderick Kingsley.
The Chameleon is actually one of Spider-man's earliest super-villains. A master impersonator, he uses his costumes for villainy and fun.
Doctor Doom is a supervillain from the Marvel Universe who is bent on world domination. He is the ruler of Latveria and the primary antagonist of the Fantastic Four.
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