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Charlotte Witter was the granddaughter of Madame Web, and an evil Spider-Woman created by Dr. Octopus.
Brian Kornfield, distraught at the fact that his mother was attacked, agreed to receive magical powers similar to Spider-Man, but instead became the monstrous Spider-X.
Spot is a Spider-Man villain with portal powers.
Steel Serpent is essentially the anti-Iron Fist.
Vincent Stegron was a SHIELD scientist who, appropriately enough, turned himself into a stegosaurus man.
Stilt-Man is generally a laughing-stock in the villainous community. He hates both Daredevil, and Spider-Man
Villainous scientist Karlin Malus was forced by The Wizard to become the new host of the Carnage symbiote.
A fictional villain in the Marvel universe with the ability to copy the physical movements of anyone he observes. He has used these skills to gain fame and fortune, and also a government mandated job.
Thanos is a purple alien from Marvel Comics. He was a final boss in Marvel Super Heroes and Marvel Super Heroes: War of the Gems, and was a playable character in Marvel vs. Capcom 2: New Age of Heroes.
A super-villain whose powers allow him to develop the solution or "answer" to whatever problem he is facing at any given time.
The Mandarin is a mad scientist and a superhuman kung fu grandmaster. He possesses ten rings, each with a different power. His primary enemy is Iron Man.
The Red Skull embodies all that oppose the United States, and wish it harm. He has fought many Marvel characters in comic books and video games, especially Captain America.
The Tinkerer is a villain in the Marvel Universe who uses his intelligence to build gadgets.
The Wink is a former stage magician. She was given teleportation and phasing powers by Niles Van Roekel.
Tiger Shark is primarily the nemesis of Namor, but he appears in Marvel Ultimate Alliance as part of Dr. Doom's Masters Of Evil.
Albino mob boss with super strength and durability.
Ultron is from the Marvel Comics universe. Ultron began his story disguised as the Crimson Cowl and is chiefly an enemy of the Avengers.
The fusion of Marvel villain Ultron and Mega Man X foe Sigma.
The Venom symbiote bonded with Spider-Man during his adventure in the first Secret Wars comic book event, Spidey rejected it when he found it was trying to bound with him. It went onto bound with Eddie Brock, Scorpion and Flash Thompson among others.
Raniero "Blackie" Drago was Adrian Toomes' cellmate and the second Vulture.
In the Marvel Universe, David Cannon has the mutant ability to spin his body rapidly, giving himself a whirlwind effect. He uses his power for his own gains.
Wolverine fought Spiderman because he thought he was being controled by the symbiiote
A former NYPD officer turned vigilante.
Powerful enemy of Thor in the Marvel Universe, and part of the Wrecking Crew.
A member of The Jury and antagonist of Venom.
Ymir is from the Marvel Comics universe. He is based on the frost giant of the same name from norse mythology.
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