They're useful SO LONG as you have a medical condition that can be treated by them. Many people who take them have no need to, or have been misdiagnosed.
And they do have side-effects, although the seriousness of the side-effects varies from mild to dangerous, depending on the drug and the dosage. My father takes Serotonin daily - and it helped. He is noticeably and visibly happier now (no he isn't "jazzed" and "peppy", just back to how he used to be - happy). He takes very little and it appears to have no side-effects. It was absolutely necessary - as he got older, he got more depressed. His life circumstances didn't change, but he just started feeling blue. He tried many non-drug routes to get rid of the problem - none worked.
I'm generally against drug use - although I recognize the importance of medical drugs, like anti-cancer drugs or anti-retroviral drugs, for treating medical diseases, it's my policy to examine whether or not I really need them. And sometimes I do. But I have noticed that some doctors (only a few bad apples) have tried to push uppers on me, when I had a case of insomnia and tiredness. In reality, all I needed was an adjustment to my sleeping cycle and less caffeine, but I got doctors trying to shove all kinds of pills down my throat. It's one thing to suggest pills to a patient who has a condition that needs them - but it's another to straight away jump to "here, take these" right out of the gate.
My brother has had to take anti-depressants. In my opinion, he doesn't need them. He only takes them around his university exams, when he's stressed out. But he's only stressed because he doesn't study hard enough. It's cases like that which don't need anti-depressants.
But of course, there are cases in which people DO need anti-depressants. People with genuine chemical imbalances in their head, which can't be treated by anything other than pills. I took a course in neurology when I was doing my under-grad - I've forgotten most of it, as it wasn't very useful to me, but I do recall learning that some cases of depression are more akin to a mental illness - receptors in the brain just don't work right no more, or certain chemicals just aren't secreted, or the vesicles containing the neurotransmitters across the synaptic gap just can't get reabsorbed. In those cases, there's nothing the sufferer can do except take medication.
So anti-depressants are valuable and can improve people's lives and are a great addition to medicine in general. But some (few) unscrupulous doctors try to push pills to patients who don't need them. Some doctors have unfortunately, taken too much of a shine to anti-depressants, viewing every case as a case that needs medication. This leads to over-prescription, and over-use. Then there are some patients who have self-diagnosed themselves with depression and have lied to a doctor to get pills they don't need. There's even more people who decide not to listen to a doctor's advice and take more than is recommended. I've seen this happen as well - the patient starts off with a small dosage, but then starts getting worse over time. Rather than report back to the doctor to discuss an appropriate course of action, the patient decides to take more of the medication, which can lead to disaster.
I'm not a doctor - although I did take medical courses and I keep up to date on medical advancements. I've read the papers and examined the studies. There are genuine cases of depression that warrant medication. There are genuine drugs that can help with those cases, and can make a positive impact. But there are also many cases that do NOT require medication, in which the drugs can make a decidedly less-than-positive impact. And just as there are drugs with mountains of stats and evidence to back up their effectiveness, there are some drugs whose studies I have read and found VERY questionable. Not every peer-reviewed paper can be treated with the same respect - I've seen a lot, and I mean a LOT of crap getting into some prominent journals. Usually these crap papers are proven wrong over the course of time and replaced with better studies.
But just so you know - be wary. Accept anti-depressants if you need to, but also be a bit inquisitive. I'm not saying you shouldn't trust your doctor. I'm saying you shouldn't really trust some pharmaceutical companies. They can do good work, I know, but they're also motivated by profit.
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