I'm surprised no one mentioned this already but SAVE YOUR GAME AND SAVE A LOT.
ME1 particularly has no check-pointing whatsoever and even if you have auto-save on, the points at which it does so is too far apart for comfort. Even on Normal I died enough where the infrequent auto-saves ticked me off a bit.
ME2 does a MUCH better job at this though. My first time through I never did a hard save as it was super generous with the auto-saves.
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