There's going to have to be some kind of event, like the Normandy crashing in between Mass Effect 1 and 2, to be the reason that all party members don't return and why Shepard will need new ones. I think the more popular ones will return though, and probably all the potential love interests too.
I think my favorite of all the loyalty missions was Jack's. She was probably the "best" character in the game, though my favorite was either Legion or Thane. I really enjoyed all of the loyalty missions though, with the exceptions of Jacob and Miranda. Even Zaeed's was pretty cool and unique.
I generally have a harder time beating handheld games because I end up putting them down when I start playing a new console game and never pick it back up. Wings of Liberty, Devil Survivor, Professor Layton and the Curious Village (though I was at the very end of that one and just stopped playing), to name a few.
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