morrelloman

Yeah never do a new game plus. You don't get to try a new class and you level faster anyway after beating it once.

Biggest badasses - Grunt and Thane
Best Abilities - Miranda  & Kasumi
Who I would roll with For Real = Garrus and Jacob

First note that this is impossible unless you go all the way in one direction the WHOLE playthru. 
Also don't do any interruptions that are opposite your stance, sometimes this yields points.
There is a glitch on Samara's mission at the very end where you can ask her "Are you OK?" an infinite number of times but it would take forever.
 
If you have all but the last bar then u can get every dialogue line. (other than bringing someone back from becoming disloyal) 
Having that high will fix your loyalty issues before they happen & you won't need to MAX out. 
 
Keys are to wait  to do:
Both Jack and Miranda's loyalty (you can do one, but wait to do the other)
Wait to do Zaeed unless you go renegade.
Tali loyalty
 
Hope that helps. Speaking of impossible, getting the no one left behind on your first play comes to mind.

While we have seen unnecessary amount of multilayer sneak into single-player games what would you think about being able to drop into someone's game as a different character?
Play alongside someone online for a random level or two as Grunt, Thane, Garrus etc? These characters are great and I want to shoot some synthetics as THEM. (Or in Grunt's case run over them like a linebacker) 
Even just adding more single-player missions where you split up your squad ala the suicide mission AND allowing you to play-thru those scenarios sans Shepard would be great fun.
Possibly something we will get in future ME games, if there are more. But a great opportunity I think to add gameplay variety to an already awesome experience that NEEDS to be addressed.

That Average Gastby, hope he does some more stuff because of the re-release. I am considering the otherwise not that cool engineer for a play-thru thanks to those vids.  

I died the most when I did that part with Vanguard. The key is to not freak out and stay put in your original cover spot. The Scions will miss 90% of the time because 
A) the platform is moving
B) they are at a different height than you and the shot gets lost.
 
If you have a sniper rifle no excuse not to murder that part.

This is all well and good folks. A new engine, all DLC! How could you beat it! 
ME1 for $15 + ME2 for $15 +  $30 of DLC still costs less. That's how.

Sweet Revenge! Cut the best part of the show? Nay, just make it its' own podcast!