Will your first run through the game be solo or multi? I'm torn personally. The game is more fun to me multi, but since all the in game cut scenes can be skipped by anyone without vote, I'm tempted to do a solo run thru first just so I don't miss anything

Clearly the focus of Diablo 3 is not story but I cant shake my obsession with seeing everything in every game I play.

I never really played D2 with randoms, so my barbarian will probably be flying solo mostly. I'll probably make a monk and a witch doctor or something to play with people though.

I'm going to do my initial normal run a solo one. For the harder difficulties I am probably going to group up with friends and fellow duders. Especially for Inferno...

Pretty much the entire reason I'm buying Diablo III is so I can play with people I know.

I'll be going solo initially than start a hardcore char when I'm about a third of the way through. I'll alternate back and forth so I'll get the story beats than play methodically with my hardcore guy/gal.

Solo. The people I play Diablo with are generally the same people who skip cutscenes and then ask you what's going on. So I'm going to try to enjoy the story/experience with the least amount of distractions.

I'll be going through with my girlfriend. I've finally convinced her to play something other than a barbarian in a game so I'm pretty excited.

I only every really play multiplayer with my bro and we're both interested in the story, so I'm not terribly worried about him skipping things. 

I think I finally played through the singleplayer of the first Diablo about four years after I had put hours into the multiplayer...

Solo, until i figure which class I like. Also, I kinda wanna see the story

If you can do your first run with friends, go with friends. If it's going to be running with randoms, I would say solo. Good old randoms usually spell trouble when a new game is released because people ether want to run through it as fast as possible, or are to lazy clueless to figure it out. The sad part is later on the randoms become more whinny because they think they know everything and you must be playing it wrong.

I'm going to do a few run-throughs of it with a couple groups of friends, after that it will probably be a mix of solo and groups if there are GB ones.

Since I have a bunch of friends getting it I'll probably be playing with a group most of the time, but I shouldn't have to worry about cutscenes being skipped too much. if they are I'll just go back and play it again and watch them and gain more levels as well :)

solo at first, I think. I have friends I might play with though so we'll see.

Solo. I'm going to try and devour every piece of lore and story and no one is going to mess with that. Plus I figure I'll have plenty more playthroughs on higher difficulties for that sweet sweet loot. There's plenty of time for friends afterwards.

Solo first. I want to see all the cutscenes and take my time exploring.

Multi up until the end of where the Beta left off (as ive already done that run like 50 times), and then back to Solo so I don't miss anything.

Probably just a game open to friends only.

Solo for normal because I am leaving on the 17th for two weeks and I want to see the whole game before I leave!

Solo! Because I'm a huge nerd that cares about the story. After Normal, it'll be MP all the way.

Randoms or with friends, just like the past.

Multi with my crew. Were not going to be skipping cutscenes so I don't have that to worry about. And in the beta I could hear the lores loudly over the taking in skype which was good.

Both, solo when my friends aren't on, multi when they are.

When friends are on, I'll play with them. If I am on by myself, I'll likely just create a game and play, and if some random joins my game and is in the same part of the game, we'll group up. 
 
I have no issue soloing when I have to in D3, but I would much rather go through with a friend.

I'd like to play with a group but no friends seems to like Diablo 3 so random guys it is.

I'll wait a few months for a few patches, balancing etc. Who knows maybe they'll get some sense and allow offline play.

Solo playing at my own pace for the story and cinematics. After playing d2 rush mode for so long it will be nice to slow down. I forgot about the "twist" at the end of d2 until watching someone play through d2 for the first time ever. Of course after seeing everything that's there, MP with buds all the way.

Solo, so I can take in the story and world - exploring the game and advancing through it at my own pace. Later I'll, of course, join up with some randoms or friends.

Solo, most of the folk I'd play with would skip all the story stuff and that drives me up the wall. 

Solo, don't want to miss on the story parts or cut scenes.

Solo, obviously. I don't want to the story ruined by having other people in the game.

Solo, my friends don't play games like Diablo.

Solo first, solo last, solo always.

Solo first, then with friends and fellow-duders.

First run through Normal solo.

I'll be playing with the hugest Diablo nerds I personally know (myself included), so always multi for me. We all care about the lore for the first normal run and by the time we've reached nightmare it will be a huge skipfest.

I got a friend who is interested in the story as much as me so it won't be a problem. Multi!

Would've been a good poll. Mainly solo at first then I'll see if I know anyone who would like to co-op with me before resorting to randoms.

None of my friends are playing D3, at least not at launch. And I'm ok with that. I want to go through normal on my own so I can enjoy it at my pace with out people talking over the game on skype.

By time I finish normal some of my friends may start playing and I'll open my games up to pubs can join for faster grinding.

But definitely solo to start!

I always found playing diablo solo was dreadfully boring.

Flying solo first then multi with the subsequent difficulties.

Solo, I dislike how you can completely miss the story stuff on multiplayer. I'd like to see it all, at least the first time around.

Solo so I can soak the story in more. My solo experience should be more pleasant now that there are check points and no corpse hunting when I die.

Gonna be doing both a solo and multi run. Probably multi as my very first, unless they somehow don't get on at launch.

Both. I'll be solo playing when I've nobody online to play with and co-oping when they are. Different characters of course.

My first run will be 4 Player co-op with friends. I'm way too excited for tonight, but I can't help it :D

Silly question, solo at first to try out the different classes, as I've seen many interesting RPG classes in the past that looked interesting but turned out weren't that much fun to play, then when I find the class or two I like then join up with friends (who played enough of the beta to know what they're going with for the main).

I will be playing multi with some friends

Running through it solo first then I'll jump into the multi.

I'm going solo the first run, not trusting no one to not skip cut scenes.

I have some days of before the weekend so going to try to finish it before and then take it multi.

Remember to turn off "Quick join" under Social in game settings, some people don't leave when asked, and there are no way to kick them.

I never did test if the Busy setting in battle.net made it so friends couldn't join.

Solo the first time through, to get the story beats, trying to parse out the story in Diablo 2 in multiplayer was an attempt at futility.