I've been slowly going through them in order from the start and really enjoy them. Some classic moments and some really interesting discussions about older games. Even gone back and played some 3 year old games after hearing them talk about them (good way to play cheap games). And some things they talk about is really interesting with the knowledge we have now (like where im up to in late 2009 Jeff starts talking about The Raid, I think thats where the idea was birthed.
So Id say if you have the time then definitely worth it.