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Shizune is the niece of Dan, the lover of Tsunade. Sometime after Dan died, Tsunade left Konoha and Shizune went with her as her attendant. The bond between Tsunade and Shizune is so strong that above all, Shizune sees her purpose in life is to take care of Tsunade. Besides being Tsunade's attendant, she is also a highly talented medical-nin and jōnin. Her talent in the medical field is rivalled only by that of Sakura Haruno and Tsunade herself.